Spironolactone CAS 52-01-7

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Spironolactone is a medication belonging to the class of potassium-sparing diuretics and aldosterone antagonists. It is widely used in the pharmaceutical industry for its therapeutic properties. Spironolactone helps regulate fluid and electrolyte balance in the body and is primarily prescribed for the treatment of conditions such as hypertension, heart failure, and edema.


  1. Hypertension Treatment: Spironolactone is commonly used as an adjunctive therapy in the management of hypertension (high blood pressure). It works by blocking the actions of aldosterone, a hormone that can contribute to increased blood pressure.
  2. Heart Failure: It is also prescribed for the treatment of heart failure, especially in patients with reduced ejection fraction. Spironolactone helps improve symptoms, reduce fluid retention, and decrease the workload on the heart.
  3. Edema: Spironolactone is utilized in the treatment of edema (fluid retention) associated with various conditions, including liver cirrhosis, nephrotic syndrome, and congestive heart failure.
  4. Hormonal Disorders: Due to its anti-androgenic properties, Spironolactone is sometimes prescribed off-label for the management of hormonal disorders such as hirsutism (excessive hair growth), acne, and polycystic ovary syndrome (PCOS).

Key Features:

  • Aldosterone Antagonist: Spironolactone acts as a competitive antagonist of aldosterone receptors, inhibiting the actions of aldosterone and promoting the excretion of sodium and water.
  • Potassium-Sparing Diuretic: It helps retain potassium in the body while increasing the excretion of sodium and water, making it useful in conditions where potassium depletion should be avoided.
  • Blood Pressure Control: By blocking aldosterone, Spironolactone helps lower blood pressure and maintain it within a normal range.
  • Hormonal Regulation: The anti-androgenic effects of Spironolactone make it effective in managing hormonal disorders characterized by excessive androgen levels.
  • Oral Administration: It is administered orally, usually in tablet form, making it convenient for daily use.

Parameter Value
Chemical Formula C24H32O4S
Molecular Weight 416.57 g/mol
Appearance White to off-white crystalline powder
Melting Point 198-200°C
Solubility Practically insoluble in water, soluble in organic solvents
Stability Stable under normal conditions
Storage Store in a tightly closed container, protected from light and moisture
Shelf Life 3 years
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Spironolactone CAS 52-01-7