Progesterone 4-Pregnene-3,20-dione CAS 57-83-0

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Progesterone is a naturally occurring hormone that plays a vital role in the female reproductive system. It is primarily produced by the ovaries during the menstrual cycle and is responsible for preparing and maintaining the uterus for pregnancy. Progesterone is widely used in the pharmaceutical industry and is available in various forms for medical applications.


  1. Hormone Replacement Therapy (HRT): Progesterone is commonly used as part of hormone replacement therapy for women who have reached menopause. It helps balance hormone levels and alleviates symptoms such as hot flashes, night sweats, and mood swings.
  2. Fertility Treatment: Progesterone is essential for supporting early pregnancy. In assisted reproductive technologies (ART) and fertility treatments, progesterone supplements are often prescribed to prepare the uterus for embryo implantation and to maintain pregnancy in women with progesterone deficiency.
  3. Menstrual Irregularities: Progesterone can be used to regulate menstrual cycles and treat certain menstrual disorders, such as irregular periods and amenorrhea (absence of menstruation).
  4. Contraception: Progesterone-only contraceptives, including birth control pills, injections, and intrauterine devices (IUDs), work by inhibiting ovulation and altering the uterine lining to prevent pregnancy.
  5. Supportive Therapy during Pregnancy: Progesterone may be prescribed during pregnancy to support a healthy pregnancy and reduce the risk of miscarriage in women with a history of recurrent miscarriages.
  6. Endometrial Hyperplasia: Progesterone therapy can be used to treat endometrial hyperplasia, a condition characterized by the overgrowth of the uterine lining, which may lead to abnormal bleeding or increase the risk of endometrial cancer.

Key Features:

  • Hormone Regulation: Progesterone helps regulate the menstrual cycle and prepares the uterus for pregnancy.
  • Bioidentical Hormone: Progesterone used in pharmaceutical preparations is chemically identical to the progesterone produced by the body.
  • Diverse Administration Methods: Progesterone can be administered orally, topically (creams, gels), intramuscularly (injections), or vaginally (suppositories) depending on the desired therapeutic effect.
  • Well-Studied Safety Profile: Progesterone has been extensively studied and used in clinical settings for decades, with a well-established safety profile.
  • Potential Side Effects: Common side effects of progesterone therapy may include bloating, breast tenderness, mood changes, and drowsiness. It is important to consult with a healthcare professional for proper administration and monitoring.

Parameter Value
Chemical Formula C21H30O2
Molecular Weight 314.46 g/mol
Appearance White or off-white crystalline powder
Melting Point 128-131°C
Solubility Slightly soluble in water, soluble in organic solvents
Stability Stable under normal conditions
Storage Store in a cool, dry place, protected from light
Shelf Life 2 years
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Progesterone 4-Pregnene-3,20-dione CAS 57-83-0